"Image Caption: The figures show that fulvestrant-mediated cytoplasmic localization of ER is associated with intermediate filament proteins CK8 and CK18. After treatment of MCF-7 and T47D cells (breast cancer cells) with fulvestrant, dramatic cytoplasmic localization of ER was observed. The results indicate that the presence of CK8 and CK18 is necessary for fulvestrant-induced cytoplasmic ..."